i writ about atropin and atropine over dose because ihad astory with acase of atropine over
sign and symptoms
include vasodilation;
drying of the mouth;
increase in pulse rate;
inhibition of contractions of the gastrointestinal tract, ureter, and bladder;
and reduction of salivary, bronchial, gastric, and sweat gland secretions.
Following clinical and larger doses, atropine sulfate causes dilation of the pupils (mydriasis) and paralysis of accommodation (cycloplegia) and, in narrow-angle
glaucoma, can increase intraocular pressure
0.5 mg -
Slight dryness of nose and mouth; bradycardia
1 mg
- Greater dryness of nose and mouth with thirst; slowing, then acceleration of heart; slight mydriasis.
2 mg -
Very dry mouth; tachycardia with palpitations; mydriasis, slight blurring of near vision; flushed, dry skin.
5 mg
- Increase in above symptoms plus disturbance of speech; difficulty in swallowing; headache; hot, dry skin; restlessness with asthenia.
10 mg and over
- Above symptoms to extreme degree plus ataxia, excitement, disorientation, hallucinations, delirium, and coma.
Contraindications
Glaucoma; adhesions (synechiae) between the iris and lens of the eye;
asthma;
Sal-Tropine is contraindicated in patients with an allergy to atropine or to sulfate.
treatment of Atropine Overdosage
a short acting barbiturate or diazepam may be given as needed to control marked excitement and convulsions.
Large doses for sedation should be avoided because central depressant action may coincide with the depression occurring late in atropine poisoning. Central stimulants are not recommended.
Physostigmine, given as an atropine antidote by slow intravenous injection of 1 to 4 mg (0.5 to 1.0 mg in children), rapidly abolishes delirium and coma caused by large doses of atropine. Since physostigmine is rapidly destroyed, the patient may again lapse into coma after one to two hours, and repeated doses may be required.
Artificial respiration with oxygen may be necessary.
Ice bags and alcohol sponges help to reduce fever, especially in children
.
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