Amebiasis ,treatment of Nematode Infections

Albendazole (Albenza-

Used for hookworm, pinworm, and roundworm. Decreases ATP production in worm, causing

energy depletion, immobilization, and, finally, death

Adult Dose
Ascariasis, enterobiasis, hookworm, or trichuriasis: 400 mg PO as single dose, may repeat in 3 wk if necessary

Strongyloidiasis: 400 mg PO qd for 3 d, may repeat regimen in 3 wk if necessary

Trichinosis: 400 mg PO bid for 15 d
Pediatric Dose
Ascariasis, enterobiasis, hookworm, or trichuriasis<2> 200 mg PO as single dose, may repeat in 3 wk if necessary>2 years: Administer as in adults

Strongyloidiasis<2> 200 mg PO qd for 3 d, may repeat regimen in 3 wk if necessary>2

years: Administer as in adults

/R

alzental tablet 200mg

single dose repeated in 3 weeks

childern more than 2y

\R

alzental susp 200mg

2bottle as single dose repeated in 3 weeks

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Amebiasis
Metronidazole (Flagyl)

Description
Active against various anaerobic bacteria and protozoa. Appears to be absorbed into cells. Intermediate metabolized compounds are formed and bind DNA and inhibit protein synthesis, causing cell death. Antimicrobial effect may be due to production of free radicals.Indicated for invasive E histolytic infections.

Adult Dose
500-750 mg PO tid for 10 d
Pediatric Dose
35-50 mg/kg PO divided tid for 10 d
Contraindications
Documented hypersensitivity
Interactions
Cimetidine may increase toxicity of metronidazole; may increase effects of anticoagulants; may increase toxicity of lithium and phenytoin; ingestion of ethanol during therapy may induce a disulfiramlike reaction with abdominal cramps, nausea, and emesis
Pregnancy
B - Usually safe but benefits must outweigh the risks.
Adjust dose in hepatic disease; monitor for seizures and development of peripheral neuropathy; alcoholic beverages should be avoided during

Precautions
administration and for 3 d after